drug tolerance


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Related to drug tolerance: drug withdrawal

drug tolerance

[′drəg ‚tä·lə·rəns]
(medicine)
Condition that may follow repeated ingestion of a drug in so that the effect produced by the original dose no longer occurs.
References in periodicals archive ?
Any patient who shows drug tolerance to antipsychotics, who needs an increasingly high dose, or who needs dual or triple therapy is a candidate for adjunctive therapy with anticonvulsants, he said.
Figuring out the exact biochemistry behind drug tolerance could lead to new strategies for undermining unusually hardy cancer cells.
One of the first signs of trouble often is drug tolerance, which means that you take increasingly larger doses to achieve the same effect.
This module reviews various antecedents that influence adolescents to initiate drug use; surveys the drugs adolescents most commonly abuse and the prevalence of drug abuse; examines the prevalence of crack and cocaine use by adolescents; provides information about the physiological effects of various drugs on body systems; examines how drugs affect the central nervous system and the implications of how those changes influence overt behavior and performance; and reviews issues of drug tolerance and physical dependence as physiological concerns.
SQI's Ig_plex products have been shown to significantly improve the drug tolerance, sensitivity and other important performance metrics through the use of its custom anti-drug-antibody (ADA) tests, ultimately resulting in better, more cost effective, and easier to obtain data.
You will find discussions of many issues and developments, including: -- Cost savings and efficiencies -- Overcoming drug tolerance and dependence -- Understanding pain pathways and mechanisms of action -- Safety and patient compliance -- Clinical evidence supporting product efficacy -- Reimbursement and legislation
Although there is no way to equate extinction "trials" in cold tolerance with "placebo" exposures in drug tolerance, the results of the present experiment may parallel other experiments (Siegel et al.
The clinician intervened with communication, optimizing drug tolerance and improving the patient's adherence.
In those territories, as in Japan, Hong Kong, Dubai , France, Ireland, England and the rest of Europe, we now run international events of championship status with a zero drug tolerance, just as in human athletics.
These interventional pain management techniques can help many patients significantly reduce their use of high-dose narcotics and thus avoid development of drug tolerance, preserving narcotics as an option for later use if they develop more diffuse pain, Dr.
This fits with induced drug tolerance, in which an addict becomes less sensitive to the euphoric effects of a drug over time, requiring increasing doses to achieve equal effect.