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The condition of having an abnormally small number of platelets in the circulating blood.



a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
There is an association between paclitaxel 's elimination half-life and the time to platelet recovery in cases of drug-induced thrombocytopenia (5), (6).
Drug-induced thrombocytopenia is a serious condition that should be considered part of the differential diagnosis in a patient with thrombocytopenia who is receiving medication.
Drug-induced thrombocytopenia is often the dose-limiting factor for many chemotherapeutic agents.
HIT is a common cause of drug-induced thrombocytopenia in hospitalized patients.

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