dysgerminoma

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dysgerminoma

[¦dis·jər·mə′nō·mə]
(medicine)
An ovarian tumor composed of large polygonal cells of germ-cell origin, resembling seminoma of the testis, but less malignant. Also known as embryoma of the ovary.
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Ovarian neoplasms Surface Origin epithelium Germ cells Frequency 65 - 70% 15 - 20% % of malignant 90% 3 - 5 % Age 20+ 0 - 25+ Types Serous Teratoma Mucinous Dysgerminoma Endometrioid Endodermal sinus Clear Cell Choriocarcinoma Brenner Origin Parenchyma (sex cord-stroma) Metastases Frequency 5 - 10% 5% % of malignant 2 - 3% 5% Age All Variable Types Fibroma Granulosa-theca cell tumor Sertoli-Leydig cell tumor Cystadenofibroma Adapted from: Robbins and Cotran; Pathologic Basis of Disease, 7th Ed Copyright [C] 2005 Elsevier Junqueira and Carneiro; Basic Histology, 11th Ed Copyright [C] 2005 McGraw-Hill Antonio Westphalen, M.
The variability of histologic appearance and immunohistochemical staining of dysgerminomas in humans compared with veterinary species is discussed.
11 MicroRNA in seminomas and dysgerminomas also cluster with embryonic carcinomas.
109,110) The risk for gonadoblastoma and dysgerminoma is estimated at 15% to 35%, and early presentations of dysgerminomas in 10- and 13-year-olds are reported.
Dysgerminomas represent 1% of all ovarian cancers but 20% to 30% of those diagnosed during pregnancy.
11) As with ovarian dysgerminomas and testicular seminomas, intracranial germinomas are known to show immunoreactivity for placental alkaline phosphatase (PLAP) in a surface membrane or, somewhat less commonly, diffuse cytoplasmic distribution.