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Elastase

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elastase [i′la‚stās]
(biochemistry)
An enzyme which acts on elastin to change it chemically and render it soluble.
Elastase 

an enzyme of the hydrolase class elaborated by the pancreas of animals including humans. Elastase catalyzes the splitting of peptide bonds in proteins, chiefly those between the radicals of neutral animo acids. It is particularly active against elastin. The enzyme is secreted in the form of inactive proelastase, which is converted to elastase by the enzyme trypsin. Elastase is found in some bacteria.
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Uninhibited elastase in the bronchial tree, because of either excess elastase or a deficiency in AAT, results in the development of basilar pulmonary emphysema (in contrast to the apical disease present in other forms of emphysema).
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lipoxygenases, cyclooxygenases, topoisomerases, human leucocyte elastase and I[kappa]B kinases are a matter of debate.
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