Inovio's proprietary electroporation
DNA delivery technology uses brief, controlled electrical pulses to increase cellular DNA vaccine uptake.
The need for premedication would limit the use of the current electroporation
technology in less serious disease applications.
The study, undertaken by VGX in collaboration with researchers at the University of Pennsylvania, tested VGX's avian influenza DNA vaccine candidate, VGX-3400, delivered via electroporation
in non-human primates following previous successful challenge studies in mouse and ferret models.
VGX and its collaborators have previously reported that PENNVAX[TM] DNA vaccines delivered with its CELLECTRA([R]) electroporation
device induced dramatic increases in T-cell and antibody-based immune responses as well as improved control of viral replication following a simian immunodeficiency virus (SIV) challenge.
This forum brought together leading scientists from academia as well as biotechnology and pharmaceutical companies and, based on their feedback, provided the strongest response to date from a growing number of these thought leaders that the solution to advancing DNA vaccines may involve electroporation
," said Dr.
Apart from the method combining Electroporation
and Radio therapy, it also contains a strategic priority date and several electrode configurations useful for us and our customers.
Adil Daud, Richard Heller et al, titled, "Phase I Trial of Interleukin-12 Plasmid Electroporation
in Patients With Metastatic Melanoma.
We are eager to pursue the application of electroporation
in a DNA vaccine setting, complementing our ongoing program with electroporation
in gene-based cancer immunotherapy," said Vijay B.
Avtar Dhillon, president and CEO of Inovio, said: "We have a productive working relationship with the US Army and are enthusiastic that they are supporting yet another research project with Inovio focused on the use of electroporation
for biodefense vaccine development.
uses the propagation of electric fields to greatly increase the uptake of DNA drugs by cells.
However, our aim has always been to also develop novel proprietary DNA vaccines, delivered via our electroporation
technology, to stimulate robust T-cell responses and produce potent anti-cancer and anti-infectious disease activity.
Samant, said, "We are pleased to advance to human safety testing our first application of the electroporation
technology licensed from Inovio.