87) Thus, "a person of ordinary skill in this field would not reasonably have predicted that the dextrorotatory enantiomer
would provide all of the antiplatelet activity and none of the adverse neurotoxicity.
In order to estimate a reliable purity by this method, the optical rotation of a pure enantiomer
must first be known, and a sufficient amount of a pure sample, for instance 20 mg or even more, must be prepared for the polarimetric measurement.
The L-Phe and D-Phe imprinted membranes prepared by AA and AN successfully recognize template facilitate permeation of template and reject other enantiomer
The two linalool enantiomers
were identified by both retention time and corresponding mass spectra (results not shown).
Baseline resolution of the 6 enantiomers
from an [alpha]-, [beta]-, and [gamma]-HBCD mixture was achieved on [beta]-permethylated cyclodextrin bonded (NUCLEODEX, Macherey-Nagel, GmbH, Diiren, Germany) chiral LC column (4 x 200 mm, 5[micro]m) .
Pharmacokinetics and pharmacodynamics of ketoprofen enantiomers
in the horse.
Generally warfarin consists of a racemic mixture of two active enantiomers
, (R)-form and (S)-form, and the metabolism and anticoagulant potency of each enantiomer
differs, with the anticoagulant action of (S)-warfarin being about 3-5 times higher than that of (R)-warfarin (Breckenridge et al.
Biological molecules, such as RNA and proteins, can exist in either a natural or unnatural form, called enantiomers
To date, there have been several methods disclosed in the literature for preparing d-threo enantiomer
of methylphenidate, the process reported first by Patrick etal, describes use of expensive resolving agent 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate in the resolution of dl-threo- methylphenidate, The Journal of Pharmacology and Experimental Therapeutics,241:152-158(1987).
129) In the past twenty years, several pharmaceutical companies have filed for and obtained patents covering single enantiomer
versions of racemic drugs already approved and on the market.
It is the worldas only single enantiomer
beta agonist, thereall never be another one.
Moreover, he found that a PHOSITA had no way of knowing what the properties of the d-enantiomer
and its salts would be without testing the individual combinations; therefore, the beneficial properties of clopidogrel were not known before the racemic mixture was separated into its enantiomers