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encephalitis lethargica

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encephalitis lethargica [en‚sef·ə′līd·əs lə′thär·jə·kə]
(medicine)
Epidemic encephalitis, probably of viral etiology, characterized by lethargy, ophthalmoplegia, hyperkinesia, and at times residual neurologic disability, particularly parkinsonism with oculogyric crisis. Also known as epidemic encephalitis; sleeping sickness; von Economo's disease.


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The neuroleptic drugs "induce a brain pathology, similar in kind to encephalitis lethargica and Parkinson's disease.
They would stand or sit in the lobby, in corridors, completely motionless, frozen into a trance-like state by encephalitis lethargica, an epidemic of sleeping sickness which, like influenza, swept the globe after the First World War.
After the encephalitis lethargica pandemic from 1917 to 1926, depression, mania, and obsessive-compulsive disorder were observed in postencephalitis patients (11).
 
 
 
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