end-product inhibition

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end-product inhibition [¦end ‚präd·əkt ‚in·ə′bish·ən]

(biochemistry)

In sequential enzyme systems, a control mechanism in which accumulation of final product from a metabolic reaction causes inhibition of product formation.

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allosteric enzyme

Furthermore, PCB-induced inhibition of DA synthesis (due either to activation of inhibitory autoreceptors or end-product inhibition due to elevations in cytosolic DA) would have consequences primarily on the RRP because the vesicular content of the RRP of DA under unstimulated conditions is replenished with DA that is either newly synthesized or recently taken up from the extraneuronal space by the DAT (Javoy and Glowinski 1971; McMillen et al.

Polychlorinated biphenyls alter extraneuronal but not tissue dopamine ... by Bemis, Jeffrey C. / Environmental Health Perspectives

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