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eosinophilic granuloma

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eosinophilic granuloma [¦ē·ə¦sin·ə¦fil·ik gran·yə′lō·mə]
(medicine)
A disease, principally of childhood, characterized by foci of bone inflammation and granulation containing lipids, mononuclear cells, and eosinophils.


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Histological and immunological studies on eosinophilic granuloma of soft tissue, so-called Kimura's disease.
The clinical and microscopic manifestation of SHML should be differentiated from malignant lymphoreticular neoplasias, such as Hodgkin's disease and monocytic leukemia, histiocytosis, rhinoscleroma, tuberculosis, juvenile xanthogranuloma, dermatofibromas, and eosinophilic granuloma, among others.
1) At that time, histiocytosis X was subdivided into three types: (1) eosinophilic granuloma, an isolated osteolytic lesion: (2) Hand-Schuller-Christian disease, a multifocal version of eosinophilic granuloma that is often accompanied by systemic manifestations; and (3) Letterer-Siwe disease, a systemic, rapidly progressive form of histiocytosis X.
 
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