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epidermal growth factor |
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epidermal growth factor [‚ep·ə¦dərm·əl ′grōth ‚fak·tər] (physiology) A polypeptide produced in animals that stimulates and sustains the replication of epidermal cells (of ectodermal or endodermal origin); its human equivalent is urogastrone. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Scientists now report that a novel agent bottles up this so-called epidermal growth factor receptor and stalls the growth of cancer cells in a lab dish. Danilenko et al investigated recombinant epidermal growth factor, keratinocyte growth factor, platelet-derived growth factor-BB, and neu differentiation factor. Because treatment by tumor promoters [12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), or tumor necrosis factor alpha (TNF[alpha])] transforms clone 41 cells to anchorage-independent and tumorigenic phenotypes, they are considered to be undergoing late-stage tumor promotion. |
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