Epimerase


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epimerase

[ə′pim·ə‚rās]
(biochemistry)
A type of enzyme that catalyzes the rearrangement of hydroxyl groups on a substrate.

Epimerase

 

any enzyme of the isomerase class that catalyzes the inversion of L- and D-isomers with several centers of asymmetry. For example, aldose 1-epimerase (a mutarotase) catalyzes the conversion of of α-D-glucose into β-D-glucose. Epimerases are widely found in nature. (SeeRACEMASE.)

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Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls.
People with galactosemia, either classic galactosemia or epimerase deficiency galactosemia, have genetic mutations that decrease their levels of the key enzymes (GALT and GALE) responsible for the metabolism of a common form of dietary sugar.
du Pont de Nemours and Company (Wilmington, DE) has patented an isolated nucleic acid fragment encoding a plant enzyme that catalyze steps in the biosynthesis of lysine, threonine, methionine, cysteine and isoleucine from aspartate, the enzyme a member selected from the group consisting of: dihydrodipicolinate reductase, diaminopimelate epimerase, threonine synthase, threonine deaminase and S-adenosylmethionine synthetase.
Galactose is then further metabolized and is converted to glucose with the help of three enzymes present on the red blood cells: galactokinase, 1-phosphate uridyl transferase, and uridine diphosphoglucose 4 epimerase.
Under the agreement with Marukin Shoyu, Cytel receives the exclusive worldwide rights to make and use "GlcNAc 2" epimerase in combination with its SNC Technology.
MI is then converted in DCI by epimerase in mammalian tissues.
Larner, "Decreased myoinositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls," Endocrine Journal, vol.