Objective: Phosphate ester hydrolysis
is one of the most important classes of chemical reactions in biology, playing a central role in nucleic acid processing, energy transduction, and signalling.
A substantial weight percent of the latent print residue is attributed to lipid components and lipids are susceptible to ester hydrolysis
Low acceleration effects of only a few percentage points caused by ultrasound have been reported for some ester hydrolysis reactions in water-organic solvents, thus temperature control is decisive in correct kinetic investigations of sonication effects .
The sonolytic degradation of 4-nitrophenol (4-NP) was also monitored in an identical manner because during the ester hydrolysis reaction under sonication this degradation can lead to defacement of the kinetic results .
The drug can only be released when it detaches from the PLA polymer chain, which occurs gradually by a reaction called ester hydrolysis
In this report we have set out a broader investigation into hydrophobic effects of aliphatic alcohols as co-solvents on ester hydrolysis in water, and studied the neutral hydrolysis of 4-nitrophenyl chloroacetate in the presence of small amounts of alcohols.
Degradation of nitrophenol under sonication can lead to defacement of ester hydrolysis kinetics and this issue has been discussed in detail in our previous paper .
Therefore, another factor must predominate over equatorial-axial effects in cycloaliphatic ester hydrolysis
Altus is also marketing ChiroKit(TM)-EH for the rapid determination of the optimal catalyst to perform chiral resolutions via ester hydrolysis
and ChiroKit(TM)-TE for the rapid determination of the optimal catalyst to resolve alcohols and amines via acylation reactions.
Because of the autocatalytic nature of ester hydrolysis
it is the most prevalent.
In addition to ChiroCLEC-PC, Altus is marketing ChiroCLEC(TM)-BL for the resolution of amino acids, peptides, chiral amines and amino acid analogs; ChiroCLEC(TM)- CR, for the resolution of acids, alcohols and esters; and ChiroKit-EH for the rapid determination of the optimal catalyst to perform chemical reactions via ester hydrolysis
ChiroKit-EH was launched in early 1995, and consists of two components, ChiroScreen(TM)-EH for identifying the right catalyst to perform an ester hydrolysis
reaction and ChiroTool(TM) for optimizing the reaction for yield and optical purity.