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Extravasation
(redirected from extravasate)

   Also found in: Dictionary/thesaurus, Medical, Legal, Wikipedia 0.01 sec.
extravasation [ik‚strav·ə′sā·shən]
(geology)
The eruption of lava from a vent in the earth.
(medicine)
The pouring out or eruption of a body fluid from its proper channel or vessel into the surrounding tissue.

Extravasation 

the accumulation of blood that has flowed out of the blood vessels into the body cavities or surrounding tissues.

Extravasation may occur when the walls of the vessels are destroyed by a mechanical injury or a pathological process (for example, tumor). It may also occur through an uninjured wall, when the permeability of the wall is increased (for example, under the influence of certain chemical substances). The discharged blood may either permeate the tissues affected by the extravasation or form a circumscribed accumulation, called a hematoma. The significance of extravasation is determined by dimensions, rapidity of development, and site of formation. When the process is minor it is resorbed without treatment. If encapsulated or suppurative, it often requires special treatment. Because extravasation may lead to the destruction of tissue, it is especially dangerous in the brain (insult).



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Choosing the transepicardial implantation rather than intracoronary administration might overcome the problems of functionally impaired stem cells to extravasate against a chemo attractant gradient to invade and home to the ischemic tissue.
The data suggest that selectin expression plays a key role in blood cancer cell homing to bone marrow, and that GlycoMimetics' lead drug candidate - pan-selectin inhibitor GMI-1070 - reduces the rate at which multiple myeloma cells extravasate from the bloodstream, thereby inhibiting homing to the bone marrow.
With an average diameter of approximately 100 nm, sphingosomes readily extravasate through these pores and accumulate within the tumor and slowly release the encapsulated drug.
 
 
 
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