factor VIII


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Related to factor VIII: Factor VIII deficiency

factor VIII

[′fak·tər ′āt]
(biochemistry)
References in periodicals archive ?
En los individuos con titulos altos y muy responsivos el tratamiento de eleccion depende de algunas variables: la concentracion del inhibidor, el grado de reactividad cruzada del inhibidor con el factor VIII porcino, la naturaleza y extension del sangrado, la disponibilidad de productos y la experiencia del medico.
The new kind, recombinant Factor VIII, is entirely artificial but is twice the cost of the highly-purified blood extract that is now widely used.
Something else besides a defect in the Factor VIII gene is causing severe hemophilia A," Antonarakis concludes.
HAVEN 3 is a randomized, multicenter, open-label, Phase III study evaluating the efficacy, safety and pharmacokinetics of Hemlibra prophylaxis versus no prophylaxis (episodic/on-demand factor VIII treatment) in people with hemophilia A without inhibitors to factor VIII.
In doing so, emicizumab provides the cofactor function of factor VIII in people with hemophilia A, who either lack or have impaired coagulation function of factor VIII1,2).
The US Food and Drug Administration (FDA) approved the drug in November 2017 for "routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and paediatric patients with hemophilia A (congenital factor VIII deficiency) with factor VIII inhibitors".
The global hemophilia treatment market segmentation is based on drug type (antifibrinolytic agents, desmopressin, plasma derived coagulation factor concentrates - factor VIII, factor IX, combination, recombinant coagulation factor concentrates - factor VIII, factor IX, combination), indication type (acquired hemophilia, hemophilia a, hemophilia b, hemophilia c), and distribution channel (e-commerce, hospital pharmacies, retail pharmacies).
In one of our earlier studies we had reported 45 documented cases with 36 (81%) factor VIII deficiency, 8 (17%) factor IX deficiency and one factor X deficiency case.
The therapeutic uses the patient's own cells that have been corrected for the factor VIII gene.
He was discharged five days later in good condition, with a PTT of 49 s, factor VIII level of 0.
All were given an infected batch of Factor VIII - a product that helps blood clot - in the 1980s.
The diagnosis was acquired haemophilia caused by the formation of factor VIII inhibitors in her serum.