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feedback inhibition

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feedback inhibition

Suppression of the activity of an enzyme by a product of the sequence of reactions in which the enzyme is participating. When the product accumulates in a cell beyond an optimal amount, it decreases its own production by inhibiting an enzyme involved in its synthesis. After the product has been used or broken down, inhibition is relaxed and formation of the product resumes. Enzymes whose ability to catalyze a reaction depends on molecules other than the substances on which they act directly are said to be under allosteric control.

feedback inhibition [′fēd‚bak ‚in·ə‚bish·ən]
(biochemistry)
A cellular control mechanism by which the end product of a series of metabolic reactions inhibits the activity of the first enzyme in the sequence. Also known as allosteric control.
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PIK3CA, AKT1 mutation and HER2 amplification gene signatures (GS) suggest predominantly negative feedback inhibition of PI3K/AKT pathway in human breast cancer (BC).
IMPAKT breast cancer conference May 2009 by Stafyla, Vania; Dua, Sascha / Advances in Breast Cancer
The most viable of these include the Error Catastrophe Theory, related to faulty molecular transcription and errors in cellular function, the Crosslinkage Theory, in which progressively increasing cross-linking between proteins slows the body functions down, and the Neuroendocrine Theory, in which changes in homeostasis and hormone levels occur through time due to an increasing loss of sensitivity of receptors to feedback inhibition.
Free Radicals Are a Major Cause of Accelerated Aging Green Coffee ... by Darrell Miller / Health, general community
Androgenic phytonutrients from herbs (such as Tribulus terrestris, Muira puama, Avena sativa and nettle leaf), amino acids (including L-arginine) and certain foods such as melons naturally increase testosterone production without the danger of negative feedback inhibition as experienced with anabolic steroids and other hormones.
Rejuvenating Sex and Health Naturally by Randy Wysong / Economics community
 
 
 
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