Menge, Synthesis of Novel 3,7- Substituted-2-(3',4'-dihydroxyphenyl) flavones
with Improved Antioxidant Activity, J.
As in the current study, 40HA was able to inhibit the growth of sarcoma180 tumor cells, and these effects might be related to its chemical constituents, particularly flavone
C/O-glycosides (P1, isovitexin-2" -O-[beta]-D-glucopyranoside + vitexin-2"-O-[beta]-D-glucopyranoside; and P2, luteolin-7-O-glucuronide), since 40HA have higher amounts of these constituents (25.
Strnad, and V Krystof, "Antiproliferative and antiangiogenic effects of flavone
eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves," Fitoterapia, vol.
reported the presence of three methoxylated flavones
, namely, sinensetin, eupatorin and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone from the methanolic leaves extracts of O.
ring (2-phenyl-4H-1-benzopyran-4-one) constitutes a large segment of natural products.
content was expressed in g rutoside/100g dried plant.
Refinement and evaluation of a pharmacophore model for flavone
derivatives binding to the benzodiazepine site of the GABA(A) receptor.
Flavonol 54% Anthocyanins 20% Flavone
8% Flavonone 7% Dihydroflavanol 4% Flavan-3-ol 4% Others 3% Note: Table made from bar graph.
NMR spectral studies revealed that the isolated fraction has two compounds, which are flavones
in nature, these are 5-hydrox-3, 7, 8, 3', 4'5'-hexamethox flavone
(1) and 3', 4', 5", 3, 5, 6, 7-heptamethoxy flavonol (2).
The primary active principles in ginkgo are flavone
glycosides and the terpene lactones bilobalide and certain ginkgolides, particularly ginkgolide B.
However, in this study, cotreatment of MCF-7 cells with kaempferol or quercetin plus 5 nM TCDD resulted in significant inhibition of TCDD-induced luciferase activity at both concentrations (1 and 10 [micro]M) of flavone
4) However, unlike the Solomon study, the used a G biloba extract known as EGb 761 that is standardized to contain 24% flavone
glycoside, 6% terpene lactones, and less than 5 ppm gingkolic acids.