fluorouracil


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fluorouracil:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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fluorouracil

[¦flu̇r·ō′yu̇r·ə‚sil]
(pharmacology)
C4H3FN2O2 Crystals that decompose at 282-283°C; used as an antineoplastic drug and as an inhibitor of deoxyribonucleic acid synthesis. Also known as 2,4-dioxo-5-fluoropyrimidine; 5-FU.
References in periodicals archive ?
It is reasonable at this point to consider the use of a standard and perhaps annual course of topical fluorouracil, 5%, to the face and ears for the reduction of SCC risk in high-risk populations, and potentially for a reduction in need for Mohs surgery; more detailed study could define precisely the groups that would most benefit," they wrote.
During the study period, more participants treated with fluorouracil had complete clearance of AKs on the face and ears, compared with the control group (P less than .
Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: A study of the Arbeitsgemeinschaft Internistische Onkologie.
Neither cryosurgery nor fluorouracil was used in 35% of U.
Taro's fluorouracil cream is a prescription pharmaceutical product used for topical treatment of multiple actinic or solar keratoses and superficial basal cell carcinomas, and is bioequivalent to Efudex[R] Topical Cream 5% of Valeant Pharmaceuticals International.
Intralesional 5- fluorouracil in the treatment of keloids: an open clinical and histopathologic study.
Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest.
Oral capecitabine was associated with equivalent disease-free survival but greater safety than intravenous bolus fluorouracil plus leucovorin as an adjuvant treatment for stage III colon cancer, reported Chris Twelves, M.
5% fluorouracil followed by cryosurgery was more effective than cryosurgery alone in a controlled study.
In the first study, researchers in the National Surgical Adjuvant Breast and Bowel Project (NSABP) studied 679 node-negative patients, finding that women given chemotherapy -- a combination of methotrexate and fluorouracil - had an 80 percent disease-free survival rate four years later, compared with 71 percent of controls.
The combination regimen CapeOX, which is capecitabine (Xeloda, Roche) and oxaliplatin (Eloxatin, sanofi~aventis), was added as an alternate option to the combination of fluorouracil, leucovorin and oxaliplatin (known as FOLFOX).