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1. FOrmula CALculator.

An interactive system written by Rick Merrill of DEC in 1969 for PDP-5 and PDP-8. It was a descendant of AID/JOSS.

Versions: FOCAL-69, FOCAL-1971, FOCAL-11 (for PDP-11 under RT-11).
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The more the number of glomeruli obtained, the easier it becomes to make a diagnosis, and in cases like Focal Segmental Glomerulosclerosis (FSGS), in which diagnosis can be missed if corticomedullary junction is not obtained and other focal diseases, it is imperative that an adequate tissue is obtained.
Our understanding of atherosclerosis has shifted from a focal disease whose hallmark is symptoms caused by a severe stenosis to a systemic disease characterized by endothelial dysfunction (ED) and plaque inflammation, with the potential for rupture and thrombosis mainly in those with subcritical stenosis.
Anderson Cancer Center in Houston reported using limited surgical resection followed by wide-field irradiation for focal disease, and they were able to treat patients with advanced disease who would have otherwise required radical excision plus radiation with or without chemotherapy.

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