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leucovorin |
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leucovorin [lü′käv·ə·rən]
(pharmacology) Folinic acid used as a calcium salt to counteract the toxic effects of folic acid antagonists and for treatment of megaloblastic anemias. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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No references found | Patients with these polymorphisms benefit from supplemental folinic acid and other nutrients needed for methylation. Standard combination chemotherapy regimens comprising 5-fluorouracil (5-FU) plus leucovorin [LV, also known as folinic acid (FA)] in combination with irinotecan, typically FOLFIRI or oxaliplatin (FOLFOX) have been reported to facilitate the resection of 9%-40% of initially unresectable metastases [1, 2], with data emerging from randomized trials suggesting that the addition of targeted agents and a third cytotoxic might be even more effective. The new research, funded by Cancer Research UK and published in the British Journal of Cancer, shows that patients who had surgery and chemotherapy with a drug called 5FU alongside folinic acid, had a five year survival rate of 24%. |
folinic acid |
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