follicle-stimulating hormone

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follicle-stimulating hormone

(FSH): see gonadotropic hormonegonadotropic hormone
or gonadotropin,
any one of three glycoprotein (see protein) hormones released by either the anterior pituitary gland or the placenta (the organ in which maternal and fetal blood exchange nutrients and waste products) that have various effects upon
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.

Follicle-Stimulating Hormone

 

(FSH), a gonado-trophic hormone in man and other vertebrates produced by the anterior pituitary.

Chemically, the hormone is a glycoprotein; its primary structure has not been established. The molecular weight of FSH in sheep is 67,000; the molecular weight for swine is 29,000. The molecule consists of two subunits, alpha and beta. The alpha sub-unit is similar to the alpha subunits of luteinizing and thyrotropic hormones, whereas the beta subunit differs from the beta subunits of these hormones. The biological properties of FSH are determined solely by the beta subunit (in lizards, the beta subunit is as active as the native hormone). In females, FSH stimulates the development of follicles up to ovulation and promotes the growth of ovarian interstitial tissue; these effects lead to an increase in the secretion of female sex hormones, or estrogens. In males, FSH promotes the growth of the seminiferous tubules and stimulates spermatogenesis and the secretion of male sex hormones, or androgens. FSH acts jointly with the luteinizing hormone.

The synthesis and excretion of FSH are regulated both by the FSH releasing factor, which is elaborated by the hypothalamus, and by the levels of androgen and estrogen in the blood; as the concentrations of androgen and estrogen increase, the secretion of FSH decreases.

REFERENCES

Pankov, Iu. A. “Struktura i svoistva gipofizarnykh gormonov,” part 2: “Belkovye gormony gipofiza.” Problemy endokrinologii, 1974, vol. 20, no. 3.
Pierce, J G. “Properties of Pituitary Thyroid-stimulating Hormone in Comparison With Those of the Gonadotropins.” Biochemical Society Transactions, 1974, vol. 2, no. 5.

V. M. SAMSONOVA

follicle-stimulating hormone

[¦fäl·ə·kəl ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein hormone released by the anterior pituitary of vertebrates which stimulates growth and secretion of the Graafian follicle and also promotes spermatogenesis. Abbreviated FSH.
References in periodicals archive ?
p,p'-DDT targets the follicle stimulating hormone receptor (FSHR) transmembrane domain.
Antral follicle count in the prediction of poor ovarian responseand pregnancy after in vitro fertilization: a meta analysis and comparison with basal follicle stimulating hormone level.
Effect of follicle stimulating hormone dosage, seasons and treatment frequency on superovulation in goats.
Somatomedin-C synergizes with follicle stimulating hormone in the acquisition of progesterone biosynthetic capacity by cultured rat granulosa cells.
The engineered T-cells will use the follicle stimulating hormone (FSH) to target ovarian cells that express the FSH-Receptor.
Serum LDL, HDL, total cholesterol, triglyceride (TG), total testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), 17b-estradiol (E2), prolactin (PRL), thyroid stimulating hormone (TSH), sex hormone binding globulin (SHBG), glucose and insulin levels were determined.
Follicle stimulating hormone and luteinizing hormone were estimated by enzyme-linked immunosorbent assay on day 3 of the cycle and the ratio was calculated.
In addition, the instrument must have the capacity to analyze the luteinizing hormone (LH) in serum and urine, follicle stimulating hormone (FSH) in serum prolactin (PRL) in serum and chorionic gonadotrophin (hCG) in serum and urine.
Use of the flare-up protocol with high dose human follicle stimulating hormone and human menopausal gonadotropins for in vitro fertilization in poor responders.
The University of North Carolina study found that the cut-offs used by such infertility tests, which measure levels of a molecule called follicle stimulating hormone or FSH, label many women as infertile who actually go on to have children naturally.
High levels of the follicle stimulating hormone, a well-known marker of poor fertility, were twice as likely in O group women.

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