follicle-stimulating hormone

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follicle-stimulating hormone

(FSH): see gonadotropic hormonegonadotropic hormone
or gonadotropin,
any one of three glycoprotein (see protein) hormones released by either the anterior pituitary gland or the placenta (the organ in which maternal and fetal blood exchange nutrients and waste products) that have various effects upon
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Follicle-Stimulating Hormone


(FSH), a gonado-trophic hormone in man and other vertebrates produced by the anterior pituitary.

Chemically, the hormone is a glycoprotein; its primary structure has not been established. The molecular weight of FSH in sheep is 67,000; the molecular weight for swine is 29,000. The molecule consists of two subunits, alpha and beta. The alpha sub-unit is similar to the alpha subunits of luteinizing and thyrotropic hormones, whereas the beta subunit differs from the beta subunits of these hormones. The biological properties of FSH are determined solely by the beta subunit (in lizards, the beta subunit is as active as the native hormone). In females, FSH stimulates the development of follicles up to ovulation and promotes the growth of ovarian interstitial tissue; these effects lead to an increase in the secretion of female sex hormones, or estrogens. In males, FSH promotes the growth of the seminiferous tubules and stimulates spermatogenesis and the secretion of male sex hormones, or androgens. FSH acts jointly with the luteinizing hormone.

The synthesis and excretion of FSH are regulated both by the FSH releasing factor, which is elaborated by the hypothalamus, and by the levels of androgen and estrogen in the blood; as the concentrations of androgen and estrogen increase, the secretion of FSH decreases.


Pankov, Iu. A. “Struktura i svoistva gipofizarnykh gormonov,” part 2: “Belkovye gormony gipofiza.” Problemy endokrinologii, 1974, vol. 20, no. 3.
Pierce, J G. “Properties of Pituitary Thyroid-stimulating Hormone in Comparison With Those of the Gonadotropins.” Biochemical Society Transactions, 1974, vol. 2, no. 5.


follicle-stimulating hormone

[¦fäl·ə·kəl ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
A protein hormone released by the anterior pituitary of vertebrates which stimulates growth and secretion of the Graafian follicle and also promotes spermatogenesis. Abbreviated FSH.
References in periodicals archive ?
Molecular cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for the [beta]-subunit of rat follicle stimulating hormone.
Ethanol and the pulsatile release of luteinizing hormone, follicle stimulating hormone and prolactin in ovatiecromized rats.
a recombinant human follicle stimulating hormone, r-hFSH, follitropin alfa, is used to substitute or enhance low or lacking naturally occurring FSH causing female and male infertility.
Day 3 follicle stimulating hormone (FSH) and estradiol (E2): could these values be used as markers to predict pregnancy outcomes in women undergoing ovulation induction (OI) therapy with intrauterine insemination (IUI) cycles?
Primary cultures of granulosa cells serve as a useful system to study hormone production in vitro because these cells respond to follicle stimulating hormone (FSH) by inducing steroidogenic enzymes and differentiation (Erickson 1983).
Naples, FL; 941-403-7261), hypothesized that estrogen itself may not necessarily be beneficial, but that follicle stimulating hormone and/or leutenizing hormone were possibly detrimental.
Dr Lalioti, as assistant professor in the Department of Obstetrics Gynecology and Reproductive Sciences at Yale, said: "When a woman undergoes in vitro fertilisation, she receives medication called Follicle Stimulating Hormone to produce more than one oocyte, which is the normal production each month.
Aetiological factors involved in the low response to gonadotrophins in infertile women with normal basal serum follicle stimulating hormone levels.
The follicle stimulating hormone application is part of Vitro's overall plan to develop a proprietary position relative to follicle stimulating hormone.
Follicle stimulating hormone test followed by human chorionic Gonadotropin test occupied third and fourth position in the market by 2019.
They looked at the signaling pathways involved in the follicles' response to follicle stimulating hormone, or FSH, which is responsible for helping a woman's body develop a mature egg.

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