follicle-stimulating hormone


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Related to follicle-stimulating hormone: luteinizing hormone, prolactin

follicle-stimulating hormone

(FSH): see gonadotropic hormonegonadotropic hormone
or gonadotropin,
any one of three glycoprotein (see protein) hormones released by either the anterior pituitary gland or the placenta (the organ in which maternal and fetal blood exchange nutrients and waste products) that have various effects upon
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.

Follicle-Stimulating Hormone

 

(FSH), a gonado-trophic hormone in man and other vertebrates produced by the anterior pituitary.

Chemically, the hormone is a glycoprotein; its primary structure has not been established. The molecular weight of FSH in sheep is 67,000; the molecular weight for swine is 29,000. The molecule consists of two subunits, alpha and beta. The alpha sub-unit is similar to the alpha subunits of luteinizing and thyrotropic hormones, whereas the beta subunit differs from the beta subunits of these hormones. The biological properties of FSH are determined solely by the beta subunit (in lizards, the beta subunit is as active as the native hormone). In females, FSH stimulates the development of follicles up to ovulation and promotes the growth of ovarian interstitial tissue; these effects lead to an increase in the secretion of female sex hormones, or estrogens. In males, FSH promotes the growth of the seminiferous tubules and stimulates spermatogenesis and the secretion of male sex hormones, or androgens. FSH acts jointly with the luteinizing hormone.

The synthesis and excretion of FSH are regulated both by the FSH releasing factor, which is elaborated by the hypothalamus, and by the levels of androgen and estrogen in the blood; as the concentrations of androgen and estrogen increase, the secretion of FSH decreases.

REFERENCES

Pankov, Iu. A. “Struktura i svoistva gipofizarnykh gormonov,” part 2: “Belkovye gormony gipofiza.” Problemy endokrinologii, 1974, vol. 20, no. 3.
Pierce, J G. “Properties of Pituitary Thyroid-stimulating Hormone in Comparison With Those of the Gonadotropins.” Biochemical Society Transactions, 1974, vol. 2, no. 5.

V. M. SAMSONOVA

follicle-stimulating hormone

[¦fäl·ə·kəl ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein hormone released by the anterior pituitary of vertebrates which stimulates growth and secretion of the Graafian follicle and also promotes spermatogenesis. Abbreviated FSH.
References in periodicals archive ?
The follicle-stimulating hormone receptor: A novel target in genitourinary malignancies.
A protocol using a low dose of gonadotrophin-releasing hormone agonist might be the best protocol for patients with high follicle-stimulating hormone concentrations on day 3.
But he is surprised that the adverse impacts are limited to just inhibin B and total testosterone, because luteinizing hormone and follicle-stimulating hormone are typically considered to be involved in similar pathways.
All-or-none N-glycosylation in primate follicle-stimulating hormone p-subunits.
Surgical histopathology showed a pituitary adenoma staining positive for TSH and human growth hormone and negative for adrenocorticotropin, luteinizing hormone, follicle-stimulating hormone, and prolactin.
Researchers from the University of Nebraska Medical Center in Omaha measured testosterone or estradiol, leuteinizing hormone, follicle-stimulating hormone, and prolactin before and 1 year after pancreas transplantation in 13 men and 10 women.
Recombinant follicle-stimulating hormone (FSH) is administered by subcutaneous (under the skin) injection with a small needle.
Secreted primarily by the hypothalamus, GnRH normally stimulates the brain's pituitary gland to make luteinizing hormone and follicle-stimulating hormone.
Follicle-stimulating hormone (FSH) now has become an established means of ovulation induction (OI) as part of assisted reproductive technology (ART).
In this issue, Hoare and colleagues (2) retrospectively investigated their single-centre database of prostate cancer patients treated palliatively with ADT for a potential association between serum follicle-stimulating hormone (FSH) levels and time to CRPC.
the most appropriate screening tests are basal follicle-stimulating hormone plus estradiol levels or antimullerian hormone levels.
And foreign brands still prevail in the markets of recombinant insulin, rhIFN, recombinant coagulation factor and recombinant human follicle-stimulating hormone (rhFSH).

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