follicle-stimulating hormone

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follicle-stimulating hormone

(FSH): see gonadotropic hormonegonadotropic hormone
or gonadotropin,
any one of three glycoprotein (see protein) hormones released by either the anterior pituitary gland or the placenta (the organ in which maternal and fetal blood exchange nutrients and waste products) that have various effects upon
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.

Follicle-Stimulating Hormone

 

(FSH), a gonado-trophic hormone in man and other vertebrates produced by the anterior pituitary.

Chemically, the hormone is a glycoprotein; its primary structure has not been established. The molecular weight of FSH in sheep is 67,000; the molecular weight for swine is 29,000. The molecule consists of two subunits, alpha and beta. The alpha sub-unit is similar to the alpha subunits of luteinizing and thyrotropic hormones, whereas the beta subunit differs from the beta subunits of these hormones. The biological properties of FSH are determined solely by the beta subunit (in lizards, the beta subunit is as active as the native hormone). In females, FSH stimulates the development of follicles up to ovulation and promotes the growth of ovarian interstitial tissue; these effects lead to an increase in the secretion of female sex hormones, or estrogens. In males, FSH promotes the growth of the seminiferous tubules and stimulates spermatogenesis and the secretion of male sex hormones, or androgens. FSH acts jointly with the luteinizing hormone.

The synthesis and excretion of FSH are regulated both by the FSH releasing factor, which is elaborated by the hypothalamus, and by the levels of androgen and estrogen in the blood; as the concentrations of androgen and estrogen increase, the secretion of FSH decreases.

REFERENCES

Pankov, Iu. A. “Struktura i svoistva gipofizarnykh gormonov,” part 2: “Belkovye gormony gipofiza.” Problemy endokrinologii, 1974, vol. 20, no. 3.
Pierce, J G. “Properties of Pituitary Thyroid-stimulating Hormone in Comparison With Those of the Gonadotropins.” Biochemical Society Transactions, 1974, vol. 2, no. 5.

V. M. SAMSONOVA

follicle-stimulating hormone

[¦fäl·ə·kəl ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein hormone released by the anterior pituitary of vertebrates which stimulates growth and secretion of the Graafian follicle and also promotes spermatogenesis. Abbreviated FSH.
References in periodicals archive ?
Serum level of follicle-stimulating hormone is associated with extraprostatic extension of prostate cancer.
Expression and cellular localization of follicle-stimulating hormone receptor in normal human prostate, benign prostatic hyperplasia and prostate cancer.
LHRH superagonists in prostate cancer: Differential effects on follicle-stimulating hormone.
Scatter plot of the correlation between maximum follicle-stimulating hormone (FSH) while on androgen deprivation therapy (ADT) with the development of castration-resistant prostate cancer (CRPC).
A protocol using a low dose of gonadotrophin-releasing hormone agonist might be the best protocol for patients with high follicle-stimulating hormone concentrations on day 3 Hum Reprod.
Limited success using the "flare" protocol in poor responders in cycles with low basal follicle-stimulating hormone levels during in vitro fertilization.
Women older than 40 years of age and those with elevated follicle-stimulating hormone levels differ in poor response rate and embryo quality in in vitro fertilization.

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