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founder effect

   Also found in: Medical, Wikipedia 0.01 sec.
founder effect [′fau̇n·dər i‚fekt]
(genetics)
The overrepresentation of a specific allele at one or more loci in a new population that arises from a small number of individuals whose small gene pool may be unrepresentative of the parental population initially or as a result of the ensuing genetic drift.
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This is known as founder effect and can be observed in geographically isolated areas and among populations that practice intermarriage based on circumstances, customs, beliefs or economics.
Marriages Among Cousins Increasing in UAE by Khaleej Times (Dubai, United Arab Emirates)
Model 3, the constrained founder effect model, also significantly increments the control model (Nagelkerke [R.
Firm founders, boards, and misleading disclosures: an examination of ... by Donoher, William J. / Journal of Managerial Issues
They are thought to account for over 80% of highly penetrant inherited breast cancer, and for about 2-3% of all breast cancer in outbred non-'founder' populations (in populations with so-called founder effects, mutations that are usually >400 years old are carried by a large proportion of the breast cancer population).
High-risk breast cancer predisposition genes by Gareth, D.; Evans, R.; Howell, Anthony / Advances in Breast Cancer
 
 
 
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