fragile site


Also found in: Medical.

fragile site

[′fraj·əl ¦sīt]
(genetics)
The chromosomal position of a deoxyribonucleic acid sequence predisposed to spontaneous or induced breakage; sometimes contains short repetitive sequences.
References in periodicals archive ?
Almost all cases of FXS are caused by the expansion of a CGG repeat in the 5' untranslated region of the fragile X mental retardation gene (FMR-1) (OMIM #309550) at the FRAXA fragile site Xq27.
Instead of a trip to Disneyland, the top prize is a $20,000 award for the winning class to continue or expand its project--whether that's protecting a local habitat, kick-starting a renewable energy effort or cleaning up environmentally fragile site.
However, if it is common to find only one copy deleted then the deletions may be passengers and it may well be a fragile site.
X-linked mental retardation, macro-orchidism, and the Xq27 fragile site.
ABSTRACT : An investigation to determine frequency and distribution of folate sensitive chromosomal fragile sites was carried out in a Pakistani breed of Lohi sheep to uncover fragile site phenomena.
The selection of Petra as one of the New Seven World Wonders, says Aysar Akrawi, PNT's executive director, "has served as a wake up call for the need to manage this fragile site.
Mexicans are beaming about the recent designation of the Chichen Itza Mayan temple city as one of the new Seven Wonders of the World in July, but the reaction is mixed on the impact that an expected surge in visitors will have on the fragile site.
They immediately notified a local archaeologist and a dig was quickly organised on the fragile site.
Although only a small fraction of the wall and its forts has been excavated, the fragile site is being eroded by heavy boots, say archaeologists.
It's exciting,'' said Parks, who is fighting to locate the dam on a less environmentally fragile site.
It is an extremely sensitive and fragile site," said Brian Mansell, head of the Tasmanian Aboriginal Land Council.
Indeed, one fragile site under suspicion--a long string of DNA on human chromosome 3 called FRA3B--is often disrupted in breast cancer, researchers reported last month in Denver at a meeting of the American Society of Human Genetics.