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frameshift mutation

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frameshift mutation [¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.


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Thus, in contrast to sickle cell disease where there is a single point mutation in all individuals, in the case of, for example, cystic fibrosis, at least 700 are known including mis-sense, nonsense and frameshift mutations, which lead to the production of a faulty protein, faulty processing, faulty regulation of the chloride channel--all of which lead to the symptoms of the disease.
This strain type contains the genes for binary toxin and has an 18-bp deletion and a frameshift mutation in tcdC hypothesized to result in deregulated expression of toxins A and B.
The mutation is caused by a number of genetic errors, including nonsense and frameshift mutations, all of which result in the loss of the ability to synthesize progranulin, said Dr.
 
 
 
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