frameshift mutation

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frameshift mutation

[¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
References in periodicals archive ?
Nonsense and frameshift mutations account for up to 48% and 32% of all small lesions in DMD patients, while nonsense and frameshift mutations represent only 24% and 16% of them in BMD patients, respectively.
The premature truncation of FrxA in nine MTZ resistant strains was caused by frameshift mutations due to nucleotide deletion including one strain at position 54 as previously reported.
Furthermore, due to the fact that the extract presented mutagenic activity to both strains suggests that the mechanism to damage the DNA involves frameshift mutations (loss or gain of a pair of bases) as substitution of a pair of bases (Benigni, 2005; King et al.
Two new frameshift mutations in exon 25 of FBN3 were also identified.
8) Most of these mutations are nonsense or frameshift mutations, leading to truncated (unstable) proteins.
However, frameshift mutations, mutation number, G:C[right arrow]A:T transitions at CpG sites, and insertions/deletions were consistently elevated among exposed subjects.
Patients with adult-onset cardiac disorders or myopathy with limb girdle distribution are often associated with frameshift mutations presumably leading to a truncated protein (22).
Thus, in contrast to sickle cell disease where there is a single point mutation in all individuals, in the case of, for example, cystic fibrosis, at least 700 are known including mis-sense, nonsense and frameshift mutations, which lead to the production of a faulty protein, faulty processing, faulty regulation of the chloride channel--all of which lead to the symptoms of the disease.
The mutation is caused by a number of genetic errors, including nonsense and frameshift mutations, all of which result in the loss of the ability to synthesize progranulin, said Dr.
Certain truncating mutations, especially frameshift mutations, appear to be linked to development of renal cancer, which was far more common in females than in males in the MCUL study.
colt in vitro model, a translesion synthesis enzyme (dinB encoded DNA polymerase IV) activity clearly promoted more important frameshift mutations (single-base deletions) in two thirds of the spontaneous mutants (10).