fumarase


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fumarase

[′fyü·mə‚rās]
(biochemistry)
An enzyme that catalyzes the hydration of fumaric acid to malic acid, and the reverse dehydration.
References in periodicals archive ?
If a patient is admitted with a suspected kidney injury, we can screen the injury using blood/urine with the help of an enzyme called fumarase, and then a scan can pinpoint where in the tissue the injury is," says one of the researchers behind the study, PhD student from the Department of Clinical Medicine at Aarhus University, Per Mose Nielsen.
Fumaric aciduria is a rare congenital metabolic disorder characterized with increased fumaric acid which occurs as a result of deficiency of fumarase which is one of the enzymes included in the tricarcoxylic acid (Krebs) cycle.
Proceeds from the fun day will be used to assist other families who have children with fumarase deficiency or other serious diseases.
1986)]: acid phosphatase (ACP), alanine dehydrogenase (ALA), butyrate esterase (EST), [Beta]-hydroxybutyrate dehydrogenase (HBD), diaphorase (DIA), fumarase (FUM), fructose-1,6-diphosphatase (F16), glucose-6-phosphate dehydrogenase (G-6), glutamic-oxalacetic transaminase (GOT), glyceraldehyde-3-phosphate dehydrogenase type 1 (GP1), isocitrate dehydrogenase (IDH), indophenol oxidase (IPO), leucine aminopeptidase (LAP), leucine tyrosine peptidase (PEP), malate dehydrogenase (MDH), malic enzyme (ME), phosphoglucose isomerase (PGI), phosphoglucomutase (PGM), 6-phosphogluconate dehydrogenase (6PGD), and shikimate dehydrogenase (SDH).
Amongst them, the fumarase is considered as the fundamental metabolic switch regulating the metabolism of matter and energy (Kosaka et al.
The team applied a novel network algorithm to a published genome-scale model of human metabolism to design minimal "knockouts" for a wide variety of metabolic functions, such as phospholipid biosynthesis and the role of fumarase in suppressing human cancer.
fumarase, fumarate reductase, citrate synthase were not isolated; however, aconitase and isocitrate dehydrogenase were isolated.
The 7-year-old, described by her mother as "the happiest little girl that you would ever meet," was diagnosed at age 2 with fumarase deficiency.
A total of 16 enzyme systems were successfully assayed, namely, adenylate kinase, aldolase, esterase, fumarase, glutamate-oxalo-acetate transaminase, [Alpha]-glycerophosphate dehydrogenase, hexokinase, hydroxybutyrate dehydrogenase, isocitrate dehydrogenase, lactate dehydrogenase, malate dehydrogenase, malic enzyme, phosphoglucomutase, 6-phosphogluconate dehydrogenase, phosphoglucose isomerase, superoxide dimutase and triosephosphate isomerase (Saura et al.