deficiency

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deficiency

Biology the absence of a gene or a region of a chromosome normally present
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Heart failure patients are thought to have functional iron deficiency if their serum ferritin level is between 100 and 300 [micro]g/L (which is frequently seen in patients with chronic inflammatory diseases) and their transferrin saturation is below 20%.
Functional iron deficiency is diagnosed when serum ferritin is 100-200% ng/ml.
The main study comes from an Italian group, but this study unfortunately showed poor sensitivities and specificities for hepcidin and also confirmed the value of hypochromic red cells in detecting functional iron deficiency.
The %LScRBC may also prove to be a useful parameter in helping to decide if a patient has functional iron deficiency.
Hemoglobin content in these cells is a better early measure of developing functional iron deficiency than most other available laboratory tests.
Intravenous ascorbic acid in haemodialysis patients with functional iron deficiency.
Comment: Functional iron deficiency is a major cause of persistent anemia in dialysis patients and also contributes to a suboptimal response to erythropoietin.
One of the most common diagnostic problems encountered by clinicians is the distinction between absolute and functional iron deficiency.
One cause for this persistent anemia may be related to a resistance to epoetin alfa due to functional iron deficiency, ultimately resulting in a state of erythropoietin hyporesponsiveness.
Furthermore, the distinction between IDA and anemia of chronic disease (ACD) has become less complicated, as has the characterization of functional iron deficiency (FID) in cases of multimorbidity in the elderly or in chronic or persisting inflammatory diseases (5-14).
Further, patients treated with FG-4592 showed no functional iron deficiency, even without the administration of intravenous iron.
This is known as functional iron deficiency (as opposed to absolute iron deficiency).

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