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Furanose

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furanose [′fyu̇r·ə‚nōs]
(biochemistry)
A sugar whose cyclic or ring structure resembles that of furan.

Furanose 

a ring-shaped monosaccharide containing a five-member furan ring. Unlike the six-member (pyranose) form, fu-ranoses are less stable and for most monosaccharides exist only in aqueous solutions and in substantially smaller quantities than pyranoses. The tendency to form a furanose ring is clearly visible, for example, in fructose, which in furanose form is also a component of many oligosaccharides and polysaccharides, such as inu-lin. Most of the monosaccharides in glycosides, oligosaccharides, and polysaccharides have the pyranose form. Glycosides in which the sugar part is represented by furanoses are called furanosides.



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The term "Locked Nucleic Acids" was coined by Exiqon to emphasize that the usual conformational freedom of the furanose ring in standard nucleosides is restricted in LNA(TM) due to a methylene linker connecting the 2'-O position to the 4'-C position.
 
 
 
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