Gamma-Aminobutyric Acid

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Gamma-Aminobutyric Acid

 

NH2CH2CH2CH2COOH, an acid formed by the decarboxylation of glutaminic acid under the action of the enzyme decarboxylase. In the body, metabolism of gamma-aminobutyric acid gives succinic acid, which participates in the tricarboxylic acid cycle. Free gamma-aminobutyric acid is found in many plants. In higher mammals gamma-aminobutyric acid is only found in the brain, where its concentration reaches 100 mg percent. Gamma-aminobutyric acid is assumed to exert a retarding action on nerve activity, which is apparently associated with its effect on the permeability of biological membranes.

References in periodicals archive ?
The treatment of dystonia and parkinsonian features include the administration of anti cholinergics, tizanidine, baclofen, levodopa, or g-aminobutyric acid agonists.
Baclofen, g-aminobutyric acid derivative, is usually used to treat skeletal spasticity or refractory hiccups in a therapeutic serum range 80-400 ng/ml.