expression has been previously reported by our group using biochemical assays and patient Ab analysis (13, 23, 24), and gangliosides
have been successfully used as targets for mAb-based therapy in melanoma (14, 25).
Director of the Parkinson's Disease Research Unit and Professor in the Department of Pathology, Anatomy and Cell Biology and the Department of Neurology at Jefferson, found that administration of GM1 ganglioside
, a substance naturally enriched in the brain that may be diminished in Parkinson's disease brains, acted as a "neuroprotective" and a "neurorestorative" agent to improve symptoms and over an extended period of time slow the progression of symptoms.
antibodies mediate complement-dependent destruction of the motor nerve terminal.
Therapeutic vaccines currently in development use antigens that are derived from proteins, carbohydrates, glycoproteins, glycopeptides, or gangliosides
, as well as attenuated tumor-associated antigens that are employed in autologous or allogeneic formulations.
Secondly, as discussed above, both CT and LT also bind with high affinity via their B-subunits to GM1 ganglioside
receptors, which are present on most mammalian cells including not only epithelial cells, such as the "M cells" covering the Peyer's patches, but also all known antigen-presenting cells (APCs); this facilitates the uptake and presentation of the toxins to the gut mucosal immune system.
beta]-hexosaminidase is a lysosomal enzyme responsible for degrading the ganglioside
Attenuation of glutamate-induced neurotoxicity in chronically ethanol-exposed cerebellar granule cells by NMDA receptor antagonists and ganglioside
She was given a new treatment called a ganglioside
cancer vaccine, which is being tested to see if it can to help the body's own defences stop the spread of malignant melanoma.
And then there's another enzyme that chops off the end sugar for GM2 ganglioside
and makes .
the attachment of the bacterial toxin of the cholera-causing organism, Vibrio cholerae, to GM1 ganglioside
receptors present on small intestinal epithelial cells).
Immunological tests revealed there were no GM1 ganglioside
antibodies or MAG antibodies in the blood.
Transport and binding proteins for ions and other small molecules 2G2 5e-14 CAGO4534 GM2 ganglioside
activator * Pufferfish AII.