gap junction


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gap junction

[′gap ‚jəŋk·shən]
(neuroscience)
An intercellular junction composed of cylindrical channels connecting adjacent cells; considered to be a low-resistance pathway for intercellular communication. Also known as communicating junction; nexus.
References in periodicals archive ?
In fact, in human GCs, hCG and ECM synergize to enhance gap junction formation and progesterone production (18).
To the best of our knowledge, there is no information reported on the relationship between the antiarrhythmic effects of Danshensu and cardiac gap junction regulation.
Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary non syndromic deafness.
Modulation of gap junction transcript and protein expression during pregnancy in the rat.
Studies on genetically engineered models of connexin43 knockout mice or of conditionally knockout mice expressing progressively decreasing levels of Cx43 and model studies showed, that reduction in gap junction content (about 40%) have only moderate or no effect on ventricular conduction velocity, but up to 95% decrease of Cx43 protein reduces conduction velocity and increases dispersion of conduction (34-36).
Both whole mounts and sections depict that muscle thickness and inflammatory infiltrate increased with infection while the distribution of Cx43-ir gap junctions remained unaltered.
While tried and true research practices furthered her understanding of gap junction mechanics, her work was jump-started by an unlikely source: geography.
Immunolocalization of gap junction protein Connexin 43 in the interstitial cells of Cajal in normal and Hirschsprung's disease bowel.
Another Upsher-Smith development program involves USL260 (tonabersat), an investigational drug in Phase I of development that is a potential first-in-class neuronal gap junction modulator that is also being explored as a potential treatment for epilepsy.
In addition, USL260 (tonabersat) is in early clinical development as a potential first-in-class neuronal gap junction modulator.
Carotenoids also may be directly anti-carcinogenic by several other mechanisms, including improved gap junction communication, enhanced immune system functioning, or antioxidant scavenging of reactive oxygen species; this may inhibit cellular dysregulation or DNA damage," researchers noted in the published study.
The researchers first used a strain of genetically mutated mice that lack a particular liver-specific gap junction.