gap junction


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gap junction

[′gap ‚jəŋk·shən]
(neuroscience)
An intercellular junction composed of cylindrical channels connecting adjacent cells; considered to be a low-resistance pathway for intercellular communication. Also known as communicating junction; nexus.
References in periodicals archive ?
Mutation analysis of gap junction protein beta 1 and genotype-phenotype correlation in X-linked Charcot-Marie-Tooth disease in Chinese patients.
It has been shown that retinal gap junctions (40,41) contribute to the neural noise reduction that is mediated by signal transmission far beyond each classical RF.
Cytokine effects on gap junction communication and connexin expression in human bladder smooth muscle cells and suburothelial myofibroblasts.
Beyer, "Oxidative stress, lens gap junctions, and cataracts," Antioxidants and Redox Signaling, vol.
The rate of expansion or proliferation of cumulus cells resulted in an increased number of high-metabolites that enter the oocyte such as inorganic ions, amino acids, sugars, nucleotides and cAMP through gap junctions.
However recommended actions of progesterone include relaxation of myometrial smooth muscle, blocking action of oxytocin and inhibition of formation of gap junctions.
Martin AO, Mathieu MN, Chevillard C, Guerineaux N (2001) Gap junctions mediate electrical signaling and ensuing cytosolic Ca2+ increases between chromaffine cells in adrenal slices: a role in catecholamine release.
In fact, in human GCs, hCG and ECM synergize to enhance gap junction formation and progesterone production (18).
To the best of our knowledge, there is no information reported on the relationship between the antiarrhythmic effects of Danshensu and cardiac gap junction regulation.
En este trabajo se asumio un remodelado simplificado de gap junction considerando: situaciones de AF, por remodelado electrico y estructurado (dilatacion), una reduccion de la conductividad del tejido en un 40 % (24), una relacion anisotropica de 10:1 en la cresta terminalis (17) y una reduccion de conductividad en el SAN (27, 28).
An investigational drug, Tonabersat is the first-in-class neuronal gap junction modulator, the company added which will be in charge of development, regulatory filing and commercialisation activities for it and based on the results of preclinical models of seizures, Upsher-Smith will develop the drug for the treatment of epilepsy.
Connexins are a family of transmembrane proteins that form intercellular gap junction channels to allow ions and small molecules between adjacent cells.