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A polypeptide hormone secreted by the pyloric mucosa which stimulates the pancreas to release pancreatic fluid and the stomach to release gastric acid.



a polypeptide hormone secreted by the mucous membrane of the pylorus of the stomach; it is secreted when the pylorus is stretched or acted on by chemical stimulants (for example, products of the decomposition of food) or impulses from the vagus nerves. Gastrin increases the secretion of gastric and pancreatic juices, as well as of bile, and alters the tone and motility of the stomach and intestines. An increase in the hydrochloric-acid content of the pylorus (when acidic gastric juice enters it) inhibits the secretion of gastrin. Two kinds of gastrin, which are very similar in structure and physiological properties, have been distinguished. Gastrin has been synthesized chemically.

References in periodicals archive ?
Variations in the sulfation of circulating gastrins in gastrointestinal diseases.
Gastrin was the first gastrointestinal hormone to be measured in plasma (1-4).
Today, the picture is changed: Peptic ulcer is caused by Helicobacter pylori infection and does not need gastrin measurement for diagnosis.
In gastrinoma cells, progastrin is processed less efficiently than in normal gastrin cells (8,25).
Patterns of gastrin components in serum during feeding in normal subjects and duodenal ulcer patients.
Gel fltration studies on immunoreactive gastrin in serum from Zollinger-Ellison patients.
The plasma samples were stored at -20 [degrees]C until the measurement of gastrin and CCK.
Although several high-titer and high-affinity antisera were C-terminal directed (1559, 1560, 1564, 8007, and 8011), they all cross-reacted with gastrin peptides to a degree making them useless for plasma measurement.
Disturbed islet-cell function related to endogenous gastrin release.
ATPase, the secretion of acid and gastrin level, but had little effect on the mucosal repair and the activity of pepsin in a PL induced ulcer.
ATPase activity and the secretion of gastrin and gastric acid in PL-induced rats.
Gastrin response to candidate messengers in intact conscious rats monitored by antrum microdialysis.