gene conversion


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gene conversion

[′jēn kən‚vər·zhən]
(genetics)
A situation in which gametocytes of an individual that is heterozygous for a pair of alleles undergo meiosis, and the gametes produced are in a 3:1 ratio rather than the expected 2:2 ratio, implying that one allele was converted to the other.
References in periodicals archive ?
Gene conversion between a linear plasmid containing a collection of silent vsp and vlp genes and another linear plasmid with an active vsp or vlp gene results in the replacement of one variable antigen gene with another downstream from a promoter (22,23).
Gene conversions and unequal crossovers between CYP21(steroid 21-hydroxylase gene) and CYP21P involve different mechanisms.
Evidence for frequent gene conversion in the steroid 21-hydroxylase P-450(C21) gene: implications for steroid 21-hydroxylase deficiency.
Evidence for frequent gene conversion in the steroid 21-hydroxylase P450 (C21) gene: implication for steroid 21-hydroxylase deficiency.
Gene conversion events that transfer this deletion to CYP21 produce a mutant allele that would not be expected to amplify when the PCR approach described here is used.
All known point mutations arising by the mechanism of apparent gene conversion were detected (Table 3).
A certain heterogeneity of mutations in the active gene has been described, such as whole gene deletion, gene conversion [5,61, and, more frequently, several common point mutations.
Aberrant splicing and missense mutations cause steroid 21-hydroxylase [P-450(C21)] deficiency in humans: possible gene conversion products.
Gene conversions and unequal crossovers between CYP21 (steroid 21hydroxylase gene) and CYP21P involve different mechanisms.
Genetically caused 21-OHD is due to large gene deletions (approximately 30 kb), gene conversions, and point mutations (including small deletions and insertions) at the CYP21A2 gene (3, 4).