gene duplication


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gene duplication

[′jēn düp·lə′kā·shən]
(genetics)
The reduction in fitness of a diploid population due to new mutant genes and those already in the gene pool.
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A newer version of the CYP450 microarray assay that directly identifies the presence of gene duplications has been developed at Roche Molecular Systems and appears to have eliminated this problem.
To confirm the presence of the *10X2 allele, we amplified an ~10-kb region (32) specific for the CYP2D6 gene duplication and used it as template to detect C188T.
Two models have been proposed to explain this phenomena; one that the nonsynonymous substitutions increase following gene duplication and preserve the duplicates through positive selection (28).
Hunt, "The Evolution of Trichromatic Color Vision by Opsin Gene Duplication in New World and Old World Primates," Genome Research 9 (1999): 629-38.
In summary, the present method offers an accurate alternative to Southern blot and other methods described previously for 21OHD diagnosis and has the following advantages: (a) it requires only a small amount of DNA (50-100 ng); (b) it is neither time-consuming (2 h) nor laborious, and can analyze many samples simultaneously; and (c) it is effective in the detection of CYP21A2 gene duplication, which is one of its most important advantages (21, 23, 25).
In one daughter lineage, gene duplication and selection achieved a new balance to develop a complex organ like an eye out of that inherent potential.
Bayesian phylogenetic analysis of nucleotide sequences placed three of the four Ceratopteris alpha-tubulin gene copies in a clade with copies from Pseudotsuga and Anemia, consistent with a history of two gene duplication events, one following and one preceding the divergence of ferns and seed plants.
Gene duplication is a process where a single gene duplicates itself by a variety of mechanisms, giving birth to another gene with a similar DNA sequence.
Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice.
30) Philippe and Forterre (31) demonstrated that the phylogenies were highly confusing due to the combining effects of gene duplication, gene loss, lateral gene transfer, and tree reconstruction artifacts.
Detection of these CYP2D6 polymorphisms results in the identification of 33 unique alleles, including seven CYP2D6 gene duplication alleles.
The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity.