gene expression


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Related to gene expression: Regulation of gene expression

gene expression

[′jēn ik¦spresh·ən]
(genetics)
The transcription, translation, and phenotypic manifestation of a gene.
References in periodicals archive ?
The 2015 Gene Expression Profiling Dashboard was developed from responses to a 21-question survey completed by 382 scientists located in North America and Europe.
Gene expression data validation is another major impediment.
Such changes are accompanied by reproducible gene expression patterns.
These data are used to assign gene expression profiles to specific modes of toxicity.
In other words, the differential gene expression patterns generated were reflective of biology regardless of the difference in technology platforms.
The FDA and many other research groups are striving to correlate content and format of gene expression microarray data with standard toxicology and pharmacology data.
The next step is image processing of each chip to generate pixel intensity and ratio measurements of each spot and eventually to determine any significant gene expression changes.
In this extensive study, a set of 330 blood samples, including 125 from patients recently diagnosed with AD, was used to generate a gene expression model for the disease and an independent test set was then used to validate the model.
Pathway-level results will be much more relevant for meaningful risk assessment than single gene expression data, they write, particularly within the regulatory arena.
Demonstrating a link between chemical exposure and gene expression profiles could pave the way for the use of carcinogen-induced changes in transcription as biomarkers to assess worker risk.
The study employed a peripheral blood-based assay with a specific Alzheimer's gene expression signature developed using DiaGenic's patented method.
FDA) (Jefferson, AR) to initiate the development of guidelines for describing toxicogenomics experiments--MIAME/Tox [see Microarray Gene Expression Data (MGED); http://www.