We will test hypotheses about: (1) the primary drivers of gene content evolution, (2) the repeatability of patterns in gene loss
and retention after WGD, and (3) the early evolution of orphan genes.
Histone acetyl transferase (HAT) gene loss
of function has emerged as a potential predictive marker of response to mocetinostat in cancer.
U of T Department of Ecology and Evolutionary Biology (EEB) professor Spencer Barrett, co-investigator of a study, said in humans, the Y chromosome has undergone extensive gene loss
over its roughly 200-million-year evolutionary history, and now retains only about three per cent of its ancestral genes.
It has been postulated that progressive gene loss
, primarily at the terminal ends of the genome, has been a driving force behind the evolution of these viruses (7).
The data revealed two unusual mishaps that occurred in the process of cell division about 27 and 80 million years ago, when an extensive expansion of genes arose from an entire extra copy of the genome, followed by extensive gene loss
30) Philippe and Forterre (31) demonstrated that the phylogenies were highly confusing due to the combining effects of gene duplication, gene loss
, lateral gene transfer, and tree reconstruction artifacts.
We think that gene loss
is still the simplest explanation," says Michael Stanhope of Glaxo-SmithKline in Collegeville, Pa.
Traces of these polyploidy events are still present, although duplication events are followed by massive gene loss
and chromosome structural rearrangements.
coli involving gene acquisition (virulence plasmid and pathogenicity islands) and gene loss
Those who did not show ERG/ETV1 genetic aberrations with no PTEN gene loss
had excellent prognosis, evidenced by an 85 percent survival rate after 11 years.
Similar evidence of substantial gene loss
in worms and flies had already emerged from comparisons of their genomes with those of several yeast species, he adds.
Graves asserted that is a "very dangerous" place as there is a lot of cell division going and with every split there is a chance for a mutation or gene loss