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gene targeting

   Also found in: Wikipedia 0.01 sec.
gene targeting [′jēn ‚tär·gəd·iŋ]
(genetics)
Replacement, by genetic engineering and homologous recombination, of a mutant (or wild-type) gene by a wild-type (or mutant) copy that may also contain a reporter gene.


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00 Hardcover Methods in molecular biology, 530 QH443 International experts in gene targeting and mouse genetics present step-by-step protocols for new and experienced researchers in genetics.
Gene targeting lets scientists inactivate or modify particular genes in mice.
Prof Smithies has used gene targeting to produce mouse models for a number of common human conditions, including high blood pressure and the blood disease thalassemia.
 
 
 
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