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general transcription factor

   Also found in: Acronyms, Wikipedia 0.04 sec.
general transcription factor [jen·rəl tranz′kript·shən ‚fak·tər]
(cell and molecular biology)
In eukaryotes, a protein that binds to ribonucleic acid polymerase to form a preinitiation complex that is necessary to begin transcription.


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In the study, Aurox researchers examined the behavior of the donor nucleus in nuclear transplant embryos and identified several nuclear defects, including assembly of the differentiated cell-specific structural protein, lamin A, enhanced content of pronuclei in TBP, a general transcription factor, and high resistance of DNA to DNAse, all of which may affect development of the embryo.
 
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