genomic stress

genomic stress

[jə¦nōm·ik ′stres]
(genetics)
Any influence that may disrupt the stability of the genome by fostering chromosome damage or mutation, such as environmental factors or altered genetic background.
References in periodicals archive ?
At lower concentrations (< 25 [micro]M), evidence of genomic stress can be observed in the form of nuclear accumulation of p53, but apoptosis is not generally seen (Dong 2002).
Bittman said, "While we were challenged at first by such a wide range of responses, closer examination of the data revealed what we eventually termed individualized genomic stress induction signatures.