carcinogen

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Related to genotoxic carcinogen: genotoxin

carcinogen:

see cancercancer,
in medicine, common term for neoplasms, or tumors, that are malignant. Like benign tumors, malignant tumors do not respond to body mechanisms that limit cell growth.
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carcinogen

[kär′sin·ə·jən]
(medicine)
Any agent that incites development of a carcinoma or any other sort of malignancy.

carcinogen

Pathol any substance that produces cancer
References in periodicals archive ?
Furthermore, with exception of "inhibition of gap junction intercellular communication" and "inhibition of senescence through activation of telomerase," a number of the mechanisms/ endpoints listed are not specific to NGTxC: oxidative stress, increased mitogenesis, interference with tubulin polymerization and so on, are also mechanisms for genotoxic carcinogens, and where negative results are recorded in the mutagenicity/genotoxicity assays, these are acceptable for mutagenesis/genotoxicity regulatory purposes.
Often being found in baked, fried or grilled foods, acrylamide is a suspected carcinogen and the UK Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment states that exposure to genotoxic carcinogens should be as low as reasonably possible.
From there, specific types of dose--response relationship, such as the sometimes controversial hormesis mechanism and always controversial biological thresholds for genotoxic carcinogens, are discussed, thereby supplementing the understanding of these latter critical concepts.
The associated genotoxic carcinogens for several of these cancers, and also heart disease causation, are heterocyclic amines produced during the broiling and frying of creatinine containing foods such as meats.
However, in the present study, which was shorter term and used a lower dose, we found no change in oxidative DNA-damage-related gene expression, nor did we find a gene expression profile characteristic of a range of genotoxic carcinogens, such as described by Ellinger-Ziegelbauer et al.
At least," he says, "there is a contrast with tobacco smoke, where genotoxic carcinogens are clearly present and involved along with other types of effects, and carcinogen-DNA adducts have been observed in the breast tissue of exposed women.