germline

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Related to germ line: germ layer, Germline mutation

germline

[′jərm ‚līn]
(biology)
A lineage of cells from which gametes are derived. Also known as germ track.
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References in periodicals archive ?
Vastly diminished or heterogeneous staining with MSH6 has been seen in association with loss of MLH1 expression (secondary to either MLH1 germ line mutation or promoter hypermethylation).
In 2006, Stanford University geneticist Andrew F ire and colleagues pointed out that the A-T tattoos were often associated with genes that are active in the germ line.
In this proposal, we will explore the functions of the X chromosome in the mammalian germ line.
They inserted DNA into the germ line, cells that pass on genes from generation to generation, of the species, creating mosquitoes with genes that prevent malaria transmission by producing malaria-blocking antibodies that are passed on to 99.
Mitochondrial transfer has been closely associated with reproductive cloning because these technologies involve alteration of germ line genetics.
Yet I was sure that scientists would research how to edit the human germ line, and quickly.
Intriguingly, the cells that serve as a germ line were derived from cheating cells whose destructive effects were tamed by integration into a life cycle that allowed groups to reproduce.
In the niche are three kinds of cells: germ line stem cells, which divide to produce sperm; somatic cyst stem cells, which make a kind of cell that helps the sperm-producing cells out; and hub cells, which make signals that keep the other two kinds of cells going.
Two mitochondrial replacement therapy scenarios would result in genetic modification of an individual's germ line, and one of these involves human reproductive cloning.
Researchers used a virus to generate transgenic animals - a foreign gene that has been deliberately inserted into the genome - on the male germ line.