germline

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Related to germ line: germ layer, Germline mutation

germline

[′jərm ‚līn]
(biology)
A lineage of cells from which gametes are derived. Also known as germ track.
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References in periodicals archive ?
We must not treat the issue of human cloning separately from the concerns raised during the HGP regarding the development of genetic therapies and somatic cell and germ line manipulation.
Originally concerned that germ line intervention could irreversibly change human nature, Anderson has recently argued that the Platonic resolution of human nature into body and soul is correct.
Juengst, "Inadvertently Crossing the Germ Line," Science 292 (2001): 397.
Dorff has raised concerns about germ line interventions leading to the pursuit of eugenics.
24) Each of these groups expresses concern about human intervention into DNA whether at the somatic or germ line level.
Because it is a surgical procedure, germ line gene therapy would be done in a medical setting and on a voluntary basis.
Those cells could then be transformed into germ line precursor cells that would eventually become eggs and sperm.
Although each identical twin inherits the same germ line DNA, both B and T cells not only rearrange that DNA but also add (and delete) non-genome encoded nucleotides to genes to make antibodies or T cell receptors, independently of antigen exposure.
As mentioned previously, this does not work in other animals because stem cells capable of producing germ line chimeras have not, so far, been reproducibly isolated except from certain strains of mice.
The considerations that have led toward public acceptance of gene therapy go like this: As long as it is somatic and abstains from tampering with the germ line, and as long as it is therapeutic and abstains from enhancement, gene therapy is okay.
Sheridan's presentation are designed to investigate integration or expression of the vaccine vector in the germ line, the persistence of the vector in the target tissue and the dissemination of the vector to non-target tissues.
Eligible patients are stratified retrospectively in Stratum A (one or more of the c-Met germ line mutations) and Stratum B (patients with no c-Met germ line mutations).