dysgerminoma

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dysgerminoma

[¦dis·jər·mə′nō·mə]
(medicine)
An ovarian tumor composed of large polygonal cells of germ-cell origin, resembling seminoma of the testis, but less malignant. Also known as embryoma of the ovary.
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The differential diagnosis for neoplastic masses in the pineal region includes GCT (pure germinoma, World Health Organization [WHO] grade 2) and nongerminomatous cell tumors, including pineal parenchymal tumors such as pineocytomas (WHO grade 1), pineoblastomas (WHO grade 4), pineal parenchymal tumors of intermediate differentiation (no current WHO grade), and papillary tumors of the pineal region (WHO grade 2-3).
15,16) Takeshima et al (17) and Sakuma et al (18) reported that they studied 16 cases of intracranial germinomas, respectively, and c-Kit was diffusely expressed on the surface of germinoma cells in all cases examined.
The good response to therapy in our patient suggests that four courses of bleomycin, etoposide, and cisplatin chemotherapy may be as effective in CNS germinoma as it is in extraneural metastatic dise ase when administered with radiotherapy, but longer follow-up and more patients treated with chemotherapy alone are needed for confirmation.
A referral was made to a neurosurgeon who believed the tumor was not a typical adenoma but more consistent with either lymphoma or germinoma.
Radiotherapy can cure almost all germinomas, and in Tim's case the tumour had disappeared after six months of intense treatment.
32) Similarly, the presence of germinoma in a congenital teratoma would be very unusual.
Despite the fact that SNTCSs do not contain elements of either yolk sac tumor, germinoma, choriocarcinoma, or embryonal carcinoma, (2,5,13,14) some authors (1,2,15) have postulated that they arise from germ cells or neural crests.
Pure germinomas are associated with very low concentrations of hCG in both serum and CSF.
Proliferative disorders in Crassostrea virginica and Mya arenaria from the Chesapeake Bay and intranuclear virus-like inclusions in Mya arenaria with germinomas from a Maine oil spill site.
Lymphocytic hypophysitis with central diabetes insipidus and consequent panhypopituitarism preceding a multifocal, intracranial germinoma in a prepubertal girl.
Again, several unusual tumor types were found, including endometrial, stomach, and cervical carcinomas, an ocular melanoma, and germinoma metastatic from pineal gland.
The germinomas very rarely calcify but may displace or engulf preexisting physiologic pineal gland calcifications.