germline


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germline

[′jərm ‚līn]
(biology)
A lineage of cells from which gametes are derived. Also known as germ track.
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Some proponents of germline engineering want to race ahead with experiments specifically designed to alter human nature, to correct "mistakes," add "improvements," or even to launch an entirely new species that will leave Homo sapiens behind.
But the argument that procedures that will be as potentially unsafe and ethically questionable as, say, germline engineering for enhancement purposes cannot in principle be regulated has no basis in past experience.
The familial harms result from the inheritable nature of germline mutations, mixed in with the fact that there are all these complex family dynamics.
In 1985, the US National Institutes of Health (NIH) approved somatic gene therapy trials, but said that it would not accept proposals for germline manipulation "at present.
In 1990, the National Institutes of Health (NIH) approved somatic gene therapy trials, but said that it would not accept proposals for germline manipulation "at present.
The Federal Circuit held both that primers are not patent eligible because they do not have a unique structure different from anything found in nature, and also that the method claims are not patent eligible because they include merely routine and conventional steps for carrying out a germline mutation screen.
An important issue is whether the offspring of these monkeys are normal, since one criticism of the technology is that a permanent change is being made to the germline and would be passed along to future generations.
Germline B cells are the major targets of modern viral vaccines, as it is the initial stimulation of these B cells and their antibodies that leads to a long-term antibody response.
Effect Germline Context Germline + context dependent dependent General An An estrogenic An antiandrogenic EDC antiandrogenic EDC alters DNA alters DNA EDC alters DNA methylation methylation in the methylation in independently male germline in a the male of the male manner that alters germline in a germline, such the organism's manner that that offspring responses to other alters the will not have environmental EDCs organism's the modified beyond the androgen responses to epigenetic pathway.
A very small percentage of chromosomal instability tumors are inherited and arise secondary to germline mutations in the APC gene (familial adenomatous polyposis; less than 1% of CRCs) or the MUTYH gene (MUTYH-associated polyposis; <1% of CRCs).
3) Familial paraganglioma syndromes are caused by germline mutations in the genes that encode for the mitochondrial enzyme succinyl dehydrogenase, and they often occur as multiple paragangliomas.
Lynch syndrome is a predisposition to certain cancers, prominently colorectal and endometrial cancers, caused by germline mutations in the genes that regulate DNA mismatch repair.