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condition in which an animal or plant is far greater than normal in size. Plants are often deliberately bred to increase their size. However, among animals, gigantism is usually the result of hereditary and glandular disturbance. Among humans, gigantism is produced by an oversecretion of growth hormones by the acidophilic cells in the anterior lobe of the pituitary, causing excessive growth of all the tissues of the body. The metabolic rate is usually at least 20% above normal, which could be caused by an excess of the growth hormone alone, or oversecretion of the thyroid hormone in addition. Usually hyperglycemia (overactivity of the insulin-producing cells of the pancreas) is present. This condition eventually leads to degeneration of the islet cells, causing diabetes. Because of these metabolic abnormalities, the life expectancy of a giant is considerably less than normal. The treatment for gigantism is usually irradiation of the pituitary. The excessive height of the pituitary giant, which is defined at various levels above 7 ft (213 cm), is caused by excessive growth of the long bones. However, if the pituitary becomes overactive after growth is complete (marked by closure of the epiphyses of the long bones), the condition known as acromegalyacromegaly
, adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small
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 results. Giantsgiant,
in mythology, manlike being of great size and strength. The giant has been the symbol for the expression of certain recurring beliefs in the mythologies of all races.
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 appear in the legends and folklore of many cultures.



excessive growth in humans. A height exceeding 190 cm may acquire a pathological character. Giants over 200 cm tall are rarely encountered; the tallest human described in the literature was 320 cm tall. Gigantism is observed more often in males, is usually manifested at nine-ten years of age or during the period of sexual maturation, and continues during the physiological growth of the body. The causes of gigantism are not known; it is presumed that it is connected with intensified function of the anterior pituitary gland, which produces the growth hormone. Giants of pathological height experience poor health and rarely live to old age. They are often psychologically infantile, and their sex drive is absent or decreased. Externally, there is elongation of the extremities, especially the lower ones; the head appears unusually small. There exists partial gigantism, which is characterized by the enlargement of part (for example, the feet) or half of the body. Treatment includes X-ray and hormone therapy, sometimes surgery.


Abnormal largeness of the body due to hypersecretion of growth hormone.
References in periodicals archive ?
Overview of acromegaly and gigantism, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines.
Our research suggests gigantism in eucalypts evolved opportunistically within the last 20,000,000 years when the ideal environmental conditions for rapid tree growth were combined with the presence of wildfire.
A cephalometric study was done on two female patients suffering from gigantism, due to excess of GH.
Vovkovinskiy, who suffers from a condition called pituitary gigantism, said all he wants are shoes that fit so he can get outside, walk his dog, and enjoy his life.
Gigantism also raises the question of maritime security and the supervision of navigation in certain zones.
Gigantism in worms may, in principle, represent an evolutionary, advantage in nutrient-deficient soils by permitting enhanced nutrient absorption due to a longer gut, but experimental support for this notion is lacking (see below).
While Fricke doesn't discount this theory, he believes that seasonal sojourns to areas rich in vegetation also played a part in the evolution of gigantism in sauropods.
His condition involves gigantism and it means he's grown out of his old seat.
After several years living in quiet seclusion, Jinny Bunford died at the age of 26 in 1922, the cause of death being given as hyperpituitarism and gigantism.
Macrodystrophia lipomatosa is a congenital local gigantism of the hand and foot characterized by proliferation of all mesenchymal components, particularly fibroadipose tissue.
00pm) Documentary about 8ft Sultan Kosen, who recalls his humble origins in Turkey, his hopes of romance and the journey to find a cure for his life-threatening gigantism.
A hand-wrist radiograph showed localised gigantism of the 2nd and 3rd digits with flexion deformity at the proximal metacarpo-phalangeal joints and soft tissue syndactyly of the 4th and 5th fingers, with fusion of the terminal phalanges.