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In contrast to GISTs, leiomyosarcomas are composed of spindle-shaped cells, with brightly eosinophilic cytoplasm, accompanied by focal or diffuse nuclear pleomorphism and high mitotic activity.
The introduction of Glivec has dramatically improved the prognosis of patients diagnosed with advanced KIT-positive GIST," said Jaap Verweij, Head of The Division of Experimental Chemotherapy, Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands, the principal investigator and lead author of this publication.
10) In 10% of cases, GISTs arise outside the tubal gut, in locations such as the mesentery, omentum and retroperitoneum, and have been referred to by the acronym EGIST (extragastrointestinal stromal tumors).
c-kit expression is not restricted to GISTs and can be seen in a variety of neoplasms including melanoma, renal cell carcinoma, and seminoma.
However, the tumor cells of GISTs in the present case had a scarcity of well-developed rough endoplasmic reticula compared with abundant free ribosomes in the cytoplasm of the tumor cell.
I immediately searched for a possible solution and found the Gleevec clinical trial, which aimed to help patients like me," said Roslyn Fuller, a GIST patient.
The gross features of GISTs usually included a granular, irregular surface with frequent areas of hemorrhage, necrosis, and cystic change (Figure 1).
It has been shown that the growth of GIST is driven by the receptor c-Kit, which depends on an enzyme called tyrosine kinase to exert its function.
We believe their results to date strongly suggest that mutation screening of both the KIT and PDGFRA genes could be of significant benefit in the management of GIST patients.
The introduction of Gleevec has dramatically improved the prognosis of patients diagnosed with advanced KIT-positive GIST," said Jaap Verweij, Head of The Division of Experimental Chemotherapy, Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands, the principal investigator and lead author of this publication.
Glivec has been available on the NHS in Scotland for the treatment of GISTs since August 2002.
Patients with double wild-type GISTs, whose tumors lack mutations in KIT and PDGFRA, constitute a very rare subpopulation of GIST patients in great need of targeted treatment options.