gliosis


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gliosis

[glī′ō·səs]
(medicine)
Proliferation of neuroglia in the brain or spinal cord, either as a replacement process or in response to a low-grade inflammation.
References in periodicals archive ?
Gliosis, which is often the result of inflammation within the brain, hints at a possible cause of the brain-cell loss in narcolepsy, says Siegel.
The hallmarks of Alzheimer's disease include senile plaques that contain amyloid [beta]-proteins (A[beta]), neuritic tangles, loss of neurons and gliosis which involves microglia and astrocytes.
Capabilities included in the showcase are efficacy disease models within Multiple Sclerosis (MS), Gliosis, Parkinson's Disease, Nociceptive, Neuropathic and Inflammatory Pain.
The presence of gliosis was assessed by incubating tissue sections with Polyclonal Rabbit Anti-Cow Glial Fibrillary Acidic Protein (Dako, Ely, UK) for 1 h at room temperature.
In reactive gliosis, the neuroprotective role of astrocytes may be accentuated because of increases in a number of activities: expression of antioxidant enzymes; transport and metabolism of glucose that yields reducing equivalents for antioxidant regeneration and lactate for neuronal metabolism; synthesis of glutathione; and recycling of vitamin C.
5) Findings that typically characterize other vascular malformations, such as calcifications, extraluminal hemorrhage, hemosiderin-laden macrophages, and gliosis (1,2,3) are typically not seen with capillary telangiectasias.
Postmortem histologic findings of brain tissue showed focal nonsuppurative encephalitis and focal gliosis with neuronal degeneration.
5,6) Whereas in AD the most striking neuronal loss and gliosis is in the entorhinal cortex and hippocampus, nucleus basalis, locus coeruleus, and neocortex, neuronal loss and gliosis in FTLD generally parallels the gross atrophy.
Beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.
Characteristic histopathologic features were nonspecific perivascular cuffing, rod cell proliferation, spongiosis, neuronal necrosis, moderate to severe gliosis, neuronal satellitosis, and neurophagia.
This condition is characterized by hippocampal atrophy and gliosis best seen on coronal T2 FLAIR imaging as hippocampal volume loss with associated increased T2 signal and loss of grey white differentiation.
There are several descriptive terms used for epiretinal membranes covering the spectrum of severity; these include terms such as cellophane maculopathy, pre-retinal macular fibrosis, gliosis, surface wrinkling retinopathy, epimacular fibrosis, pre-macular fibroplasia and various combinations of these terms.