globoside


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globoside

[′glō·bə‚sīd]
(biochemistry)
A glycoside of ceramide containing several sugar residues, but not neuraminic acid; obtained from human, sheep, and hog erythrocytes.
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References in periodicals archive ?
St represents the glycolipid standards, ceramide monohexoside (CMH), ceramide dihexoside (CDH), Globoside (Glob), Forssman glycolipid (Forss) and asialo GM1.
Acid [beta]-glucosidase is responsible for the cleavage of the [beta]-glucosidic bond of its primary substrate glucosylceramide, an intermediate in the catabolism of globoside and gangliosides.
8) To further analyze the immune response to globoside and Forssman antigens we immunized rabbits with globoside.
Antibodies specific for globoside or Forssman fall into that category.
k] phenotype results from an inability to synthesize globoside from globotriaosyl ceramide, whose concentration is increased in [P.
k] and p erythrocytes, especially the absence of globoside, the most abundant GSL, did not appear to affect the structure or function of the cells.
Potent GCS inhibitors reduce glucosylceramide (GlcCer), the substrate of GBA and the storage material in Gaucher, and also higher glycosphingolipids including gangliosides and globosides, the causative storage materials in Tay-Sachs disease, GM1 gangliosidosis and Fabry disease.