globulin


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Related to globulin: immune globulin, gamma globulin, alpha globulin

globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.

Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
Managing immune globulin therapy and achieving positive results in a complex patient population is a multifaceted challenge due to product variations, administration considerations, patient monitoring, reimbursement challenges, and increasing data requirements.
In this study, juvenile wild whooping cranes had significantly lower total protein, albumin, [alpha]-1, [alpha]-2, and [beta] globulin concentrations and a decreased A: G ratio when compared with wild adults.
Gamma globulin can cause such side effects as rashes and hives, and, in rare cases, fever.
Subcutaneous immune globulin is used to treat a medical condition called Primary Immune deficiency (PI),usually considered to be genetic group of disorders currently affecting an estimated 50,000 Americans.
Some of the gamma globulin will come from local hospitals, while the bulk will come from a Michigan supplier, Fannin said.
The company has one product on the market today: Nabi-HB(R) [Hepatitis B Immune Globulin (Human)].
7 mg of a mixture of two MAbs had the same neutralizing activity as 100 mg-170 mg of tetanus immune globulin (90).
6) for [gamma] globulin concentrations, while the remainder of the eagles had IoIs for y globulins between 0.
CSP, MSCS, AAHIVP, Director of MHA Specialty Clinical Services stated, "MHA is pleased to announce the availability of CTM for Immune Globulin therapy.
Rabies -- (HyperRAB[TM] S/D, Rabies Immune Globulin [Human])
Based on calculations of TP and the albumin fraction obtained by the biuret method and the BCG method, respectively, 5 protein fractions were identified in the electrophoretogram: prealbumin, albumin, alpha globulin, beta globulin, and gamma globulin (Fig 2).
Over the last year, Octapharma has collaborated with the FDA in analyzing the issue of procoagulant activity in industry-wide immune globulin products, which in some cases lead to TEEs in many IVIG products on the market today.