glucocorticoid


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Related to glucocorticoid: mineralocorticoid, Glucocorticoid receptor

glucocorticoid

[¦glü·kō¦kȯrd·ə‚kȯid]
(biochemistry)
A corticoid that affects glucose metabolism; secreted principally by the adrenal cortex.
References in periodicals archive ?
The goal of the treatment is to replace glucocorticoid that will permit a reasonable quality of life (2), (3).
Increasing lines of evidence indicate that the glucocorticoid receptor (GR) is regulated not only by mitogen-activated protein kinase (MAPK) signaling but also by phosphatidylinositol 3-kinase (PI3K).
This is the first study to uncover the role played by glucocorticoids in transmission.
We studied the rhythmic expression of clock genes in white blood cells to see how they adjusted in response to glucocorticoids.
However, these effects occur at much higher concentrations than those used in this study (10-100 [micro]M); when the results of the receptor knockdown experiments are considered, the glucocorticoid antagonist properties of Gen appear to be mediated through ER[alpha] for those genes studied (Barnes et al.
Accelerated atherosclerosis in systemic lupus erythematosus has been attributed to the disease or to glucocorticoid therapy.
Epidural injections of glucocorticoids plus lidocaine proved ineffective at improving pain or function in older adults with central spinal stenosis in a double-blind, randomized, controlled trial performed at 16 medical centers across the United States.
Glucocorticoids given by injection or in oral form (termed systemic therapy) confer a higher risk of side effects, while non-systemic therapy using inhalers and lotions has a lower risk-but the actual risk had not been quantified.
It appears that the initial decrease in attained height that was associated with the use of inhaled glucocorticoids in pre-pubertal children persisted as a reduction in height as adults.
The researchers concluded that in the treatment of lumbar spinal stenosis, epidural injection of glucocorticoids plus lidocaine offered minimal or no short-term benefit compared with epidural injection of lidocaine alone.
Even at the low dose, skin thinning and ecchymoses represent one of the most common glucocorticoid adverse events.
The researchers found that adults with a history of childhood adversity-maltreatment or parental loss-had increased methylation of the glucocorticoid receptor (GR) gene, which is thought to change the way this gene is expressed on a long-term basis.

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